Not known Details About thr77
Not known Details About thr77
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The antibody is from purified rabbit serum by affinity purification by using sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
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Overexpression of the gene has become observed in many tumors, which leads to chromosome instability, and therefore may possibly lead to tumorigenesis. This protein was identified to associate with, and be associated with, the phosphorylation of NPAT protein (nuclear protein mapped towards the ATM locus), which participates in mobile-cycle controlled histone gene expression and performs a vital position in promoting cell-cycle development from the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode unique isoforms, happen to be described. Two additional splice variants ended up documented but comprehensive nucleotide sequence information will not be but available.
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Blocking peptides are peptides that bind especially into the target antibody and block antibody binding. These peptide usually includes the epitope identified by the antibody.
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This tutorial outlines even further achievable optimization of cellular and immunoassay parameters to ensure the very best benefits are...
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This tutorial outlines further more possible optimization of mobile and immunoassay parameters to ensure the best possible outcomes are...
Antibodies bound to the blocking peptide no longer bind towards the epitope around the target protein. By comparing the staining from the blocked antibody as opposed to the antibody by yourself, one can see which staining is certain.
Goal Info Cyclin E belongs towards the highly conserved cyclin family, whose members are characterised by a spectacular periodicity in protein abundance throughout the cell cycle. Cyclins perform as regulators of CDK kinases. Various cyclins show unique expression and degradation patterns which add to your temporal coordination of every mitotic occasion. Cyclin E sorts a fancy with and functions as a regulatory subunit of CDK2, whose exercise is required for mobile cycle G1/S transition. This protein accumulates in the G1-S section boundary and is also degraded as cells progress by S stage.
The measurement of protein phosphorylation is a useful tool for measuring the modulation of receptor activation by both equally antibodies...
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